Midazolam efectos secundarios pdf

Midazolam is a white to light yellow crystalline compound, insoluble in water. Midazolam is a pregnancy category d drug, which means it could harm an unborn baby. Midazolam is a benzodiazepine benzoedyeazeehpeen sedative. The renal clearance of the 1hydroxymidazolam glucuronide was prolonged in the arf group 4 vs 6 mlmin and the halflife was prolonged 12 vs 25 hours. Medicamentos, accion terapeutica, propiedades, indicaciones, dosificacion, efectos secundarios, precauciones, advertencias, contraindicaciones. Midazolam side effects, dosage, interactions drugs. Midazolam accumulates in adipose tissue, which can significantly prolong sedation, especially in patients with obesity, hepatic impairment or renal impairment. It works by inducing sleepiness, decreasing anxiety, and causing a loss of ability to create new memories. Chemically, midazolam hcl is 8chloro6fluorophenyl1methyl42himidazo1,5a1,4benzodiazepine hydrochloride. The first dose of midazolam for seizures must be administered either intranasally or by intramuscular injection unless a patent intravenous cannula is already in situ. Midazolam was administered as an infusion 5 to 15 mghr. Midazolam may also be used for purposes not listed in this medication guide. See warnings concerning serious cardiorespiratory events and possible paradoxical reactions. Side effects of midazolam injection midazolam, warnings.

The hydrochloride salt of midazolam, which is formed in situ, is soluble in aqueous solutions. Midazolam use by intranasal administration patient education dis086 12116 children use midazolam as part of their treatment plan to manage seizures. Trastornos del sistema nervioso central y periferico y psiquiatricos. There have been reports of overdosage when high strength midazolam has been used for conscious sedation. The use of highstrength midazolam 5mgml in 2ml and 10ml ampoules, or. All intravenous midazolam is to be diluted with sodium chloride 0. Midazolam, a watersoluble benzodiazepine, has received considerable attention as a rectally administered drug for premedication or sedation. Midazolam is a shortacting benzodiazepine derivative with an imidazole structure and with anxiolytic, amnestic, hypnotic, anticonvulsant and sedative properties. This handout explains how midazolam works and how to give the medicine by way of the nose a method called intranasal administration. Midazolam is used to sedate a person who is having a minor surgery, dental work, or other medical procedure. Midazolam exerts its effect by binding to the benzodiazepine receptor at the gammaaminobutyric acid receptorchloride ionophore complex in the central nervous system cns. Fluctuations in vital signs were the most frequently seen findings following parenteral administration of midazolam in adults and included decreased tidal volume andor respiratory rate decrease 23. You shouldnt be given this medicine while you are pregnant.